After reading the recent https://www.thenation.com/article/society/progressive-left-philanthropy-strategy/ and many similar articles, my understanding is that proponents of "system level" changes are sceptical of a neoliberal/market-driven approach, and want a more centrally planned economy, where opportunities and outcomes are guaranteed to be more equal, or at least everyone is guaranteed a basic amount of wealth.

My understanding is that they care primarily about things like increased inequality, homelessness and unemployment in the United States, and they believe that main causes for those issues are the greed of the top 0.01% and market regulations (or lack thereof) which favour the richest at the expense of the poorest.

So I would imagine that reading things like:

AGOA gives Sub-Saharan African countries duty-free access to the American market for a range of product categories — in particular, apparel, which has historically been a key stepping stone for countries pursuing export-led manufacturing growth. [...] With Chinese labor costs increasing and general protectionist pressures growing, there may be a window of opportunity for African manufacturing industries to grow before automation in high-income countries potentially leads to significant re-shoring — provided that AGOA does not expire beforehand. Advocating for a strong AGOA renewal bill could improve the odds for an African industrial transformation.

They would expect an AGOA renewal to increase inequality and unemployment in the US by replacing American jobs with sweatshops in countries with lower minimum wage/worker rights, enriching capitalists who would profit from exploiting less protected workers.

But this is definitely a position I struggle to understand, so it's likely that I'm misrepresenting it and would welcome other guesses/corrections.