This is the kind of thing I would like to see more of. I would not invest myself because all investments seem to be in individual projects - I would want to be able to invest in some fashion in a "basket" of companies and/or projects (ideally through a large, well-known investment company like Vanguard...)

I know your long run goals are the least "binding" but I would encourage you to be a little more cautious and evidence-based in your approach to growth as an intervention. Economic growth clearly offers benefits overall in developing countries but it would surely be safer to say your objective should be to study the relationship between economic growth and human development and work to understand the circumstances in which aid that enhances economic growth in particular circumstances is more effective than alternative forms of aid.

You've reminded me about Dollar Street: https://www.gapminder.org/dollar-street/matrix which does the same thing as Children Just Like Me but online and interactive.

Hadn't thought of that - seems a likely explanation!

The discussion about Fistulas was here https://blog.givewell.org/2008/08/20/fistula/

In one of the discussions, a founder of Operation Fistula turned up. It's a horrible-sounding condition - described in the disability weighting as "has an abnormal opening between her vagina and rectum causing flatulence and feces to escape through the vagina. The person gets infections in her vagina, and has pain when urinating." It's caused if you don't have access to a C section when giving birth and can be remedied for $288. (The report's a little unclear, suggesting that the operation value lasts for 10 years - perhaps it stops working? Perhaps the lifespan of typical sufferers is in any case low?) Anyway, worth looking at if you are interested in this area.

Thanks for the additional readings. I think Paul Dolan is asking the right questions. I am disappointed that after a promising initial discussion eight years ago, Holden doesn't seem to have spoken again on the subject and to the best of my knowledge there is still no way on GiveWell to put different weights on "impact" to give different results.

I don't understand your last paragraph though. DALYs don't seem to measure economic effects on others at all, so if you do start to consider them wouldn't that be a big argument to make some DALYs negative?

NB smile.amazon.com works like smile.amazon.co.uk. Having written to Amazon Smile they responded: " We are currently working on expanding the AmazonSmile program to other countries.

You are correct in stating that customers can currently support organizations in one of the 50 United States, Germany, Austria, or the United Kingdom."

And moreover it doesn't just improve vision, it removes a source of intense pain.

A note on OPIS - might I suggest finding a way to separate your work on animal suffering from that on human suffering - at least for potential funders? Of course I can understand that you see work on both as important but there will be potential donors/supporters (myself included) who would be very inclined to support your advocacy work on easing provision of opioids for humans but who don't see the relief of animal suffering as a priority and who would not wish their support for one to be used for the other.