It looks like there might be confounders in the time series because there is a negative "effect" on life satisfaction prior to becoming disabled or unemployed. (With divorce and widowhood it's plausible that some people would see it coming years in advance.)

Academics will not find a new journal run by non-academics credible, much less prestigious. No one would be able to put this journal on an academic CV. So there's really no benefit to "publishing" relative to posting publicly and letting people vote and comment.

Metformin isn't a supplement though. It's unlikely it would ever get approved as a supplement or OTC, especially given that it has serious side effects.

Really interesting. I appreciate you sharing this and your attitude toward this. Good luck with your career in philosophy - epistemic honesty will take you far.

You might consider cross-posting this on a site like Medium to reach a larger audience.

It's not either/or. It's likely not to be a single disease - would probably be more accurate to call it a syndrome.

Technology to do something like this is already being developed, but it's not nanotechnology: https://www.nature.com/articles/nmeth.3151

Nanotechnology is rarely the most practical way to probe very small things. People have been able to infer molecular structures since the 19th century. Modern molecular biology/biochemistry makes use of electron microscope, fluorescent microscopy, and sequencing-based assays, among other techniques.

What do you mean by nanoscale neural probes? What are the questions that these probes would answer?